Be Honest and Positive
It can be tempting to lie about your reasons for seeking employment, especially if you were fired from your last job. However, this is not a good idea - most companies' do some sort of background checks and find you at some point. If you were fired, then try to explain: why, in a positive way; perhaps saying that you were not a good fit for the company, but you have learned from experience and now know exactly what you want. The same is true if you quit your job. If you are still employed, then tell the interviewer about your hopes and plans for the future, not saying that you hate your current job.
Be prepared
The key is being prepared. Presume that your interviewer will ask about your reasons for seeking employment, listing some ways to answer the questions beforehand, and if possible, practice your interviewing skills by role playing with a friend. Being caught on the hop could mean that you stammer and stutter your way through an answer without having the opportunity to sell yourself like what to do. If you are really concerned about the right impression, then it may be a good idea to contact a career counselor - to be able to give you some tips to improve your presentation.
Do not run by your Former Employer
If the reason for leaving your last job was because of bad relations with your boss or coworkers, not be tempted to criticize in the interview, however much they deserve it. Potential employers shall ensure that you are a troublemaker and did not fit well in a team of people - this can be very far from the truth, but are being tried in a brief interview and do not know the situation completely. If you cannot say anything positive about your former employer, then adhere to talk about work and not be tempted to get personal.
Being Different
Preparing to be asked about your reasons for seeking employment put some thought into why you want the new job. It can be as simple as needing a job paying bills, or wanting a job with better training and promotion opportunities. However, think of some specific reasons, in particular those that fit the job you are applying for, and put them in the most original form as possible. In this way, stand out among the crowd and, even if your employer is concerned about his reasons for leaving your last job, he / she may be willing to overlook it. Just do not be tempted to be different to make excess clothing or makeup, especially if you are applying for a professional job.
Do not over-do things
It may be tempting, especially when you get upset, to explain in great detail why you left your last job. This is not really necessary. Your potential employer is interested in the basics, but need not know the pros and cons - if they do, then you will be asked. If you talk too much, then it is more likely to spill the beans on a problem in your last job, when you are trying to avoid saying something negative. If you slip, then try to resurrect the situation as quickly as possible, without panic.
A job interview is almost always a nerve-tense experience, especially if your last job was not happy, but with some foresight, be able to stand at the trust and make sure the job for which you are interviewing is for you. If you seem to have confidence in yourself, you will be catching!